Jokate Mwegelo attended St. Anthony Secondary School from January 2000, where she received her ordinary secondary education, graduating in 2003 with a Certificate of Secondary Education. She served as Assistant Head Girl from 2002 to 2003. In 2002, during the Model United Nations General Assembly in Tanzania she was appointed to serve as the Secretary General.
Jokate was born on 20 March 1987, in Washington, D.C., where her parents worked. She was raised in Dar es Salaam, Tanzania. She started primary school at Olympio Primary School, where she served as a prefect.
Mwegelo is a member of Chama Cha Mapinduzi the dominant and ruling party in Tanzania. She was appointed as the Acting Secretary of Public Relations and Mobilization in the youth wing of the ruling party UVCCM. She was among the 450 members of the party that contested to be elected to represent Tanzania as a member in the East African Legislative Assembly.
From a young age Mwegelo has shown leadership trait, starting as a prefect in primary school. She went on to serve as Assistant Head Girl at St. Anthony Secondary School from 2002 to 2003, during the time she was also appointed as the Secretary General for Model United Nations General Assembly in Tanzania in 2002. In high school at Loyola High School from 2004 to 2006 she served as a prefect in charge of coordinating club activities at the school from 2004 to 2005. In 2005 she was elected as Head Prefect until 2006 when she graduated high school. Mwegelo leadership career excelled during her time in university where she was engaged in various activities including being vice-president of marketing and public relations for the International Students Week in Tanzania from 2007 to 2008 and in 2009 she became the President of the International Students Week in Tanzania. She was the founder and coordinator of University of Dar Es Salaam United Nations Association Chapter in 2008. Mwegelo was the project creative coordinator of United Nations Association initiative together with UNIFEM on 16 days against violence on women and girls in 2009. She was appointed as the local ambassador for the Live Global Run water initiative in 2010. In 2011, she was appointed as Ambassador for the Walk for Water initiative that benefitted 100,000 villagers in Bagamoyo, 2011.
On 28 July 2018, President John Magufuli appointed her to serve as the District Commissioner of Kisarawe District and was sworn in on 3 August 2018.